She NEVER had issues with her BP before. No noticeable side effects. I take the nicotine as lozenges to counteract the sedation from the opiates. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Less meltdowns. But it isn't a fix-it-all for me. Take care and go up slowly on the memantine. It is taken by mouth. I can not say enough good things about this medication. Helps my cognitive functions Cough 4. I hope this works on her for long long time.”, For Alzheimer's Disease: “Problem. It’s been 2 months now and she is aware and able to go for walks by herself; dress herself and play the piano. Also avoid Haldol. And prescribed Dement (memantine). Press J to jump to the feed. Patient forgets recent events and the doctor told us it was due to insufficient blood supply to the brain. Then memantine is pulled into the channel to its binding site. If I avoid Nicotine, my withdrawals are much easier and last a shorter amount of time. Problems The largest known ingestion of Memantine worldwide was 2 grams. She was withdrawing into herself and had little awareness of her surroundings and had difficulty with dressing and toileting. Of course, it will be a different reaction for everyone; not everyone is the same. This help me with social interaction. He just passed away from surgery complications but after being off it he was NORMAL. My brain felt slow, my whole body felt heavy, and walking was really hard because of the dizziness. Once she started Namenda within second week it was like she was back to her old self. Consequently, there is a large pool of high-quality evidence that supports memantine’s use in moderate-to-severe cases of Alzheimer’s disease (AD). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Asking the doctor 'what other drug may work'? Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. For Alzheimer’s disease, doctors can prescribe a … I wish you the best in your w/d man. His hallucinations have disappeared along with his garbled sentences. But it has been 2 years since she started this medication. I'm really glad this medication works so well for so many people, but the side effects were too much for me to handle.”, For Autism: “I take 20mg of Memantine for my slight autism! The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The starting dose of 10mg made her very sleepy , after consulting with the geriatrician ( psychiatrist) it was increased to 15 mg and the changes were almost instant. If anything, memantine will for a while make smoking or using nicotine lose its reinforcing effects. Sorry so many people have not been helped as he has but I can say Thank God it works great for him so far.”, Namenda (memantine) for Alzheimer's Disease: “My mother has taken aricept for 5 years. Memantine is a prescription drug. And if you can get a hold of some, ibudilast is showing great promise for people with addictions due to its unique effect on microglial inflammation. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. She started it at stage 4. I am more polite. Nine of 11 studies included in the meta-analysis used Neuropsychiatric Inventory, 13 and the other two studies 14,15 used the Behavioral Pathology in Alzheimer’s Disease Rating Scale. Available for Android and iOS devices. It is pretty bad autism. MEMANTINE/N-METHYL-D-ASPARTATE (NMDA) ANTAGONISTS; Moderate Interactions. Not a full fix for me but huge help. Immediately (2 days) condition worsens to hallucinations and confusion. But again, you've trampled on those by using nicotine for so long that it's really a moot point. After 2 weeks, I've had to cut my adderall dose almost in half (from 25mg to 15mg) because 25mg is WAY too strong now. The doctor had him on so many meds, this being one along with Zoloft. It has changed my life for the better. Thinking she is ready for a increase where she is getting her nighttime/early morning bad dreams back again. But if you have been an avid nicotine user for a long time, that upregulation you're speaking of has already essentially happened. I'm taking her off of it immediately.”, For Alzheimer's Disease: “I haven't experienced this firsthand but I've been researching this drug thoroughly, and I am conflicted with it's efficiency. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. When you first start taking this medication, you will usually take it once daily. Helps me think So in a way it will only help you out. She recommended Nameda. My brother also has been giving our dad dioralyte for dehydration and movicol to help his bowel movements and a combination of all these seem to have greatly improved dads whole well being.”, For Migraine: “Very happy with this drug! Finally, you can get a 360ml solution (2mg/ml). She immediately stopped taking this medication after that incident.”, For Migraine: “I tried memantine for my migraines. This drug should not be used!”, For Autism: “I take 10mg twice daily for autism spectrum disorder. He has been on the medication for about 6 weeks and I see a huge improvement. Then his doctor prescribed Marixino and it literally has been a complete turn around. 6.6 Special precautions for disposal and other handling. If the pump does not function as described during intended use and according to instruction, the patient should consult the treating physician or a pharmacist. If your dose is different, do not change it unless your doctor tells you to do so. But because it also antagonizes nicotinic receptors, you will lose a certain amount of overall dopaminergic tone, especially if you quit smoking at the same time. Memantine is great. My mother's confusion has amplified. It is less preferred than acetylcholinesterase inhibitors such as donepezil. [157] Therapeutic doses (~10 mg) of memantine induced a mild altered state with cognitive stimulation and altered thought patterns with some parallels to low dose arylcyclohexylamines… No help at all and they wanted my dad to take more! Better behavior.”, Namenda (memantine) for Alzheimer's Disease: “My PCP put me on Namenda to supplement my Aricept for Alzheimer's Disease . The first week on it he was sleepy and mean, but this subsided. It will not only help relieve withdrawal symptoms but it will help make less dope get you to your sweet spot, so to speak. I started at 5 mg and titrated up to 10 mg after a week. The memantine dosage will differ based on the use case. I read reviews and it can be a mess just after a few days. MEMANTINE is used to treat dementia caused by Alzheimer's disease. I would also recommend NAC to inhibit overall glutamate overactivity during this time. It was truly unbelievable. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Head Pain Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. Usual Adult Dose for Alzheimer's Disease: IMMEDIATE-RELEASE: Week 1: 5 mg orally once a day. She is doing well now. They first prescribed Aricept, which caused nausea. Learn more about Medicare prescription drug plans and savings with GoodRx. This is a generic drug. The frequency of headaches was greatly reduced and even the ones I did have were much milder sometimes to the point that I didn't have to use my usual triptan. Discussion of nootropics and cognitive enhancers. She was tired the first week but that was good rather to rest than to be awake delusional. These medications may cause some risk when taken together. When it is working I can think clearly. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. I don't abuse my friends and family, my anxiety is significantly lessened, and I can act normally in social situations. 10mg x2 a day as separate doses =20mg Namenda is available in 5mg and 10mg capsules and as an oral solution of a strength equivalent to 2 mg of Memantine HCL in each ml. We took her off the medication and she is slowing gaining her speech and mobility back. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. I am now at 15 mg for the last few weeks to see if I can get any further improvement. Give it at least 2 weeks same time daily. Take this medication by mouth with or without food as directed by your doctor. She had to go to the ER due to a subconjunctival hemorrage which was very scary! Follow your doctor's instructions carefully. More frequently reported side effects include: constipation, headache, and hypertension. These mind altering drugs are BAD! I was able to have my mom back for two years until stroke. Thanks for the thorough reply. Using it with 100mg Luvox and 450mg Wellbutrin for OCD. Medicare coverage and pricing details for Memantine. Memantine Dosage. I see no real positive effects. She and I were lucky.”, For Alzheimer's Disease: “My mom is on memantine and donep for alzheimer's for past 6 months. The side effects are really bad and requires additional medication. Namenda XR. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Not sure if there is any permanent damage from the drug yet but definitely will never let her take it again.”, Namenda (memantine) for Alzheimer's Disease: “Horrible drug! “I take 10mg memantine daily for mood instability related to bipolar disorder type 2. Comments: This drug should be initiated the day following the last dose of memantine and donepezil administered separately. Please everyone please give this medication time to work. Dizzy 6. This help me with anxiety. I am sure my nACh receptors are quite upregulated, but when I quit opoids, if I keep them upregulated (via Nicotine), I am absolutely miserable. I tell everyone. My heart goes out to every person who has to go through that, and their families as well.”, “My husband is the patient. Namenda, Time will tell I saw help on day one. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice daily), 15 mg/day (5 mg and 10 mg as separate doses), and 20 It is a miracle medicine. Does it have any effects on the nicotinic receptors? It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions. The neurologist prescribed Aricept which did not show much improvement but soon he decided to try memantine 5mg morning and night. Had to go back on Wellbutrin to stay awake. He told us to reuse memantine and by the third day the negative side effects we were back. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), … Marketing authorisation holder. Confused 2. 14 days ago, the Dr. added Memantine (generic Namenda). Diarrhea 5. 2 DOSAGE AND ADMINISTRATION The recommended starting dose of NAMENDA is 5 mg once daily. Week 4/Maintenance Dose: 20 mg orally/day (Administer 10 mg twice a day.) 7. It did not rectify some of the mental losses, but she no longer experienced hallucinations (in jail; on a boat). This information is NOT intended to endorse any particular medication. The extended release is better for the Alzheimer's patients. For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. So I waited for two weeks without drug to resume insurance at the first of the year. The amount of medicine that you take depends on the strength of the medicine. Being able to understand nonverbal communication and verbal communication is huge improvements. My question is, will the nicotinic antagonistic properties of Memantine make me feel worse during my Nicotine/Opioid withdrawal - in a similar way that Nicotine by itself does? See below for a comprehensive list of adverse effects. As of tomorrow it will be taken off”, For Alzheimer's Disease: “My mum was put on memantine just over a year ago for symptoms from vascular dementia. Patient was clearly getting better in fact even the recent memory was getting better, with the vitamins. Years of Benzos, alcohol, and Ambien took it's toll on my memory.”, For Alzheimer's Disease: “My mother and stepmother both have dementia. amazing”, “I take 10mg memantine daily for mood instability related to bipolar disorder type 2. Memantine is used off- label in a number of areas and active clinical investigations are ongoing including use in depression, ADHD, pain and more. I have researched the side affects and confusion is one of them. She was extremely agitated, angry and weepy. She was able to get up her her self dressed like she had did prior to the alzheimers. In the middle she missed her pill for 1 week and her condition became worse like hallucinations, forgetting family members and not dressing properly. The patient had consumed Memantine in conjunction with unspecified anti-diabetic medications. Although not all of these side effects may occur, if they do occur they may need medical attention. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Went back to the neurological doctor and explained every thing to him. Week 2: 10 mg orally/day (Administer 5 mg twice a day.) What about just using NAC instead? Press question mark to learn the rest of the keyboard shortcuts. It also reduces repetitive behaviour/stereotypes. My mother was on the Exalon patch and my stepmother is on donepazil and memantine. But there will be a certain foggy headedness to it, due to its effect on nicotinic receptors. Recently she has become very quiet and less chatty so the dose has been increased to 20mg. Treatment should only be continued if beneficial effects are seen. Helps me slow down my mind to pay attention more and can respond to changes and sensory problems. Seems to help my short term memory. Last week her doctor said disease progressing too fast so put her on Memantine. It comes in three forms: immediate-release tablet, oral solution, and extended-release capsule. There are a number of reasons why memantine would be useful for dealing with opiate withdrawal. The Luvox is a different story. I'm 62 and thankful for this medication.”, Namenda (memantine) for Alzheimer's Disease: “Mother-in-law has Alzheimer’s and it was severe to where she went into a memory care. Took some two other vitamins from a pharmacist for 3 months. I am also prescribed clonidine and trazadone to help me with the withdrawal rituals. Week 3: 15 mg orally/day (Administer 5 mg and 10 mg as separate doses.) After taking only four pills she could not speak, could not move her legs, had no idea where she was. I always use Nicotine with my Opioids, and never just take one or the other. Constipation 3. As with any drug, it may not work for others, but it was truly a God-send for my sweet mother. Broken shoulder then a broken wrist. It also helps with my obsessive and aggressive problems! As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies. As soon as I started it again, she improved-true testament. I always use Nicotine with my Opioids, and never just take one or the other. We comply with the HONcode standard for trustworthy health information -, Drug class: miscellaneous central nervous system agents, Miscellaneous central nervous system agents. The less you take the better. Dr. Added namenda immediately caused two falls. New comments cannot be posted and votes cannot be cast. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Helps my expressive myself and respond better. Work up to the maintenance dose. I haven't noticed any side effects, maybe a little brain fog, but that has disappeared with continued use.”, For Alzheimer's Disease: “Started this about 5 weeks ago and take 10mg 2x daily. Causes mood swings.”, Namenda (memantine) for Alzheimer's Disease: “Three days in to this drug and find the condition worsening for mom dramatically”, For Alzheimer's Disease: “My father has been diagnosed with dementia he was gradually getting worse not recognizing us ( his adult children) and not sure which era he was in ( he is 92 years of age) then he started wandering on the road my mum was at her wits end looking after him. For Autism: “A life saver. But if what you really wanted was reassurance that using Memantine while withdrawing from opiates is a good idea, then YES, absolutely it is. My period is also now 9 days late and I know I'm not pregnant and I have never missed a period in my life. Not too many side effects to date. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. Side Effects. I've been on memantine for around 2 weeks now, started at 5mg and bumped up to 10 after a week. I have autism. It became a miracle. Took 2.5mg to start off low today too see if it'll help. r/MemantineHCl: A sub for discussing all uses of Memantine, from therapeutic to recreational. Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. About 3 years ago he started having memory problems to the point of not remembering the day of the week or what he had just eaten. Medicine has given us more time with our loved one the sedation from the opiates by the day! 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